Control Analysis of Protein-Protein Interaction Network Reveals Potential Regulatory Targets for MYCN.

ABSTRACT:

Background

MYCN is an oncogenic transcription factor of the MYC family and plays an important role in the formation of tissues and organs during development before birth. Due to the difficulty in drugging MYCN directly, revealing the molecules in MYCN regulatory networks will help to identify effective therapeutic targets.

Methods

We utilized network controllability theory, a recent developed powerful tool, to identify the potential drug target around MYCN based on Protein-Protein interaction network of MYCN. First, we constructed a Protein-Protein interaction network of MYCN based on public databases. Second, network control analysis was applied on network to identify driver genes and indispensable genes of the MYCN regulatory network. Finally, we developed a novel integrat

SUBMITTER: Pan C 

PROVIDER: S-EPMC8096904 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature