Ontology highlight
ABSTRACT:
SUBMITTER: Engelke DS
PROVIDER: S-EPMC8097010 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Engelke D S DS Zhang X O XO O'Malley J J JJ Fernandez-Leon J A JA Li S S Kirouac G J GJ Beierlein M M Do-Monte F H FH
Nature communications 20210504 1
Survival depends on a balance between seeking rewards and avoiding potential threats, but the neural circuits that regulate this motivational conflict remain largely unknown. Using an approach-food vs. avoid-predator threat conflict test in rats, we identified a subpopulation of neurons in the anterior portion of the paraventricular thalamic nucleus (aPVT) which express corticotrophin-releasing factor (CRF) and are preferentially recruited during conflict. Inactivation of aPVT<sup>CRF</sup> neur ...[more]