Slit/Robo Signaling Regulates Multiple Stages of the Development of the Drosophila Motion Detection System.

ABSTRACT: Neurogenesis is achieved through a sequence of steps that include specification and differentiation of progenitors into mature neurons. Frequently, precursors migrate to distinct positions before terminal differentiation. The Slit-Robo pathway, formed by the secreted ligand Slit and its membrane bound receptor Robo, was first discovered as a regulator of axonal growth. However, today, it is accepted that this pathway can regulate different cellular processes even outside the nervous system. Since most of the studies performed in the nervous system have been focused on axonal and dendritic growth, it is less clear how versatile is this signaling pathway in the developing nervous system. Here we describe the participation of the Slit-Robo pathway in the development of motion sensitive neuron

SUBMITTER: Guzman-Palma P 

PROVIDER: S-EPMC8097104 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature