A Hypothesis for Theta Rhythm Frequency Control in CA1 Microcircuits.

ABSTRACT: Computational models of neural circuits with varying levels of biophysical detail have been generated in pursuit of an underlying mechanism explaining the ubiquitous hippocampal theta rhythm. However, within the theta rhythm are at least two types with distinct frequencies associated with different behavioral states, an aspect that must be considered in pursuit of these mechanistic explanations. Here, using our previously developed excitatory-inhibitory network models that generate theta rhythms, we investigate the robustness of theta generation to intrinsic neuronal variability by building a database of heterogeneous excitatory cells and implementing them in our microcircuit model. We specifically investigate the impact of three key "building block" features of the excitatory cell model t

SUBMITTER: Skinner FK 

PROVIDER: S-EPMC8097141 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature