Acoel Single-Cell Transcriptomics: Cell Type Analysis of a Deep Branching Bilaterian.

ABSTRACT: Bilaterian animals display a wide variety of cell types, organized into defined anatomical structures and organ systems, which are mostly absent in prebilaterian animals. Xenacoelomorpha are an early-branching bilaterian phylum displaying an apparently relatively simple anatomical organization that have greatly diverged from other bilaterian clades. In this study, we use whole-body single-cell transcriptomics on the acoel Isodiametra pulchra to identify and characterize different cell types. Our analysis identifies the existence of ten major cell type categories in acoels all contributing to main biological functions of the organism: metabolism, locomotion and movements, behavior, defense, and development. Interestingly, although most cell clusters express core fate markers shared with oth

SUBMITTER: Duruz J 

PROVIDER: S-EPMC8097308 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature