Reaching Deeper: Absolute In Vivo Thermal Reading of Liver by Combining Superbright Ag₂S Nanothermometers and In Silico Simulations.

ABSTRACT: Luminescent nano-thermometry is a fast-developing technique with great potential for in vivo sensing, diagnosis, and therapy. Unfortunately, it presents serious limitations. The luminescence generated by nanothermometers, from which thermal readout is obtained, is strongly distorted by the attenuation induced by tissues. Such distortions lead to low signal levels and entangle absolute and reliable thermal monitoring of internal organs. Overcoming both limitations requires the use of high-brightness luminescent nanothermometers and adopting more complex approaches for temperature estimation. In this work, it is demonstrated how superbright Ag₂S nanothermometers can provide in vivo, reliable, and absolute thermal reading of the liver during laser-induced hyperthermia. For that, a

SUBMITTER: Lifante J 

PROVIDER: S-EPMC8097345 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature