Dataset Information

Reaching Deeper: Absolute In Vivo Thermal Reading of Liver by Combining Superbright Ag₂S Nanothermometers and In Silico Simulations.

ABSTRACT: Luminescent nano-thermometry is a fast-developing technique with great potential for in vivo sensing, diagnosis, and therapy. Unfortunately, it presents serious limitations. The luminescence generated by nanothermometers, from which thermal readout is obtained, is strongly distorted by the attenuation induced by tissues. Such distortions lead to low signal levels and entangle absolute and reliable thermal monitoring of internal organs. Overcoming both limitations requires the use of high-brightness luminescent nanothermometers and adopting more complex approaches for temperature estimation. In this work, it is demonstrated how superbright Ag₂S nanothermometers can provide in vivo, reliable, and absolute thermal reading of the liver during laser-induced hyperthermia. For that, a new procedure is designed in which thermal readout is obtained from the combination of in vivo transient thermometry measurements and in silico simulations. The synergy between in vivo and in silico measurements has made it possible to assess relevant numbers such as the efficiency of hyperthermia processes, the total heat energy deposited in the liver, and the relative contribution of Ag₂S nanoparticles to liver heating. This work provides a new way for absolute thermal sensing of internal organs with potential application not only to hyperthermia processes but also to advanced diagnosis and therapy.

SUBMITTER: Lifante J

PROVIDER: S-EPMC8097345 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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Publications

Reaching Deeper: Absolute In Vivo Thermal Reading of Liver by Combining Superbright Ag<sub>2</sub>S Nanothermometers and In Silico Simulations.

Lifante José J Shen Yingli Y Zabala Gutierrez Irene I Rubia-Rodríguez Irene I Ortega Daniel D Fernandez Nuria N Melle Sonia S Granado Miriam M Rubio-Retama Jorge J Jaque Daniel D Ximendes Erving E

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20210303 9

Luminescent nano-thermometry is a fast-developing technique with great potential for in vivo sensing, diagnosis, and therapy. Unfortunately, it presents serious limitations. The luminescence generated by nanothermometers, from which thermal readout is obtained, is strongly distorted by the attenuation induced by tissues. Such distortions lead to low signal levels and entangle absolute and reliable thermal monitoring of internal organs. Overcoming both limitations requires the use of high-brightn ...[more]

PMID: 33977056

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Project description:Since silver nanowires (AgNWs) show high infrared reflectance many studies present their applicability as thermal management products for various wearable textiles. However, their use for practical purposes is only partially evaluated, without focusing on improving their low atmospheric and liquid stability. This report describes a new approach for the topic and proposes a facile method of Ag nanowire passivation with a SnO2 layer for high environmental stability and retention of high infrared reflectance. The one-step passivation process of AgNWs was carried out in the presence of sodium stannate in an aqueous solution at 100 °C, and resulted in the formation of core/shell Ag/SnO2 nanowires. This study presents the morphological, chemical, and structural properties of Ag/SnO2NWs formed with a 14 nm thick SnO2 shell, consisting of 7 nm rutile-type crystals, covering the silver metallic core. The optical properties of the AgNWs changed significantly after shell formation, and the longitudinal and transverse modes in the surface plasmon resonance spectrum were red shifted as a result of the surrounding media dielectric constant changes. The passivation process protected the AgNWs from decomposition in air for over 4 months, and from dissolution in a KCN solution at concentrations up to 0.1 wt%. Moreover, the report shows the microwave irradiation effect on the shell synthesis and previously synthesised Ag/SnO2NWs. The post-synthesis irradiation, as well as the SnO2 shell obtained by microwave assistance, did not allow long-term stability to be achieved. The microwave-assisted synthesis process was also not fast enough to inhibit the formation of prismatic silver structures from the nanowires. The Ag/SnO2NWs with a shell obtained by a simple hydrolysis process, apart from showing high infra-red reflectance on the para-aramid fabric, are highly environmentally stable. The presented SnO2 shell preparation method can protect the AgNW's surface from dissolution or decomposition and facilitate the designing of durable smart wearable thermal materials for various conditions.

Dataset Information

Reaching Deeper: Absolute In Vivo Thermal Reading of Liver by Combining Superbright Ag₂S Nanothermometers and In Silico Simulations.

Publications

Reaching Deeper: Absolute In Vivo Thermal Reading of Liver by Combining Superbright Ag<sub>2</sub>S Nanothermometers and In Silico Simulations.

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Dataset Information

Reaching Deeper: Absolute In Vivo Thermal Reading of Liver by Combining Superbright Ag2S Nanothermometers and In Silico Simulations.

Publications

Reaching Deeper: Absolute In Vivo Thermal Reading of Liver by Combining Superbright Ag<sub>2</sub>S Nanothermometers and In Silico Simulations.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Reaching Deeper: Absolute In Vivo Thermal Reading of Liver by Combining Superbright Ag₂S Nanothermometers and In Silico Simulations.