Adaptive Processes Change as Multiple Functions Evolve.

ABSTRACT: Epistasis influences the gene-environment interactions that shape bacterial fitness through antibiotic exposure, which can ultimately affect the availability of certain resistance phenotypes to bacteria. The substitutions present within blaTEM-50 confer both cephalosporin and β-lactamase inhibitor resistance. We wanted to compare the evolution of blaTEM-50 with that of another variant, blaTEM-85, which differs in that blaTEM-85 contains only substitutions that contribute to cephalosporin resistance. Differences between the landscapes and epistatic interactions of these TEM variants are important for understanding their separate evolutionary responses to antibiotics. We hypothesized the substitutions within blaTEM-50 would result in more epistatic interactions than for blaTEM-85 As expected

SUBMITTER: Mira PM 

PROVIDER: S-EPMC8097417 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature