Early-life heterologous rhinovirus infections induce an exaggerated asthma-like phenotype.

ABSTRACT:

Background

Early-life wheezing-associated respiratory tract infection by rhinovirus (RV) is a risk factor for asthma development. Infants are infected with many different RV strains per year.

Objective

We previously showed that RV infection of 6-day-old BALB/c mice induces a mucous metaplasia phenotype that is dependent on type 2 innate lymphoid cells (ILC2s). We hypothesized that early-life RV infection alters the response to subsequent heterologous infection, inducing an exaggerated asthma-like phenotype.

Methods

Wild-type BALB/c mice and Rora^fl/flIl7r^cre mice lacking ILC2s were treated as follows: (1) sham on day 6 of life plus sham on day 13 of life, (2) RV-A1B on day 6 plus sham on day 13, (3) sham on day 6 plus RV-A2 on day 13, and (4) RV-A

SUBMITTER: Rajput C 

PROVIDER: S-EPMC8097639 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature