Expression analysis of progesterone‑regulated miRNAs in cells derived from human glioblastoma.

ABSTRACT: Glioblastomas (GBMs) are the most frequent and malignant type of brain tumor. It has been reported that progesterone (P4) regulates the progression of GBMs by modifying the expression of genes that promote cell proliferation, migration and invasion; however, it is not fully understood how these processes are regulated. It is possible that P4 mediates some of these effects through changes in the microRNA (miRNA) expression profile in GBM cells. The present study investigated the effects of P4 on miRNAs expression profile in U‑251MG cells derived from a human GBM. U‑251MG cells were treated for 6 h with P4, RU486 (an antagonist of the intracellular progesterone receptor), the combined treatment (P4+RU486) and cyclodextrin (vehicle) and then a miRNA microarray analysis conducted. The expressi

SUBMITTER: Velazquez-Vazquez DE 

PROVIDER: S-EPMC8097752 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature