Potential role of m6A RNA methylation regulators in osteosarcoma and its clinical prognostic value.

ABSTRACT:

Background

Osteosarcoma is a disease with high mortality in children and adolescents, and metastasis is one of the important clinical features of osteosarcoma. N6-Methyladenosine (m6A) is the most abundant methylation modification in mRNA, which is regulated by m6A regulators. It is reported that it is related to the occurrence and development of tumors. However, the mechanism of its action in osteosarcoma is rarely known. The purpose of this study was to identify the potential role of m6A regulatory factor in osteosarcoma and its clinical prognostic value.

Methods

Here, we used The Cancer Genome Atlas (TCGA) to comprehensively analyze the relationship between m6A regulatory factors and osteosarcoma (metastasis group and non-metastasis group). We analyzed their survival rela

SUBMITTER: Liu H 

PROVIDER: S-EPMC8097785 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature