Genome-wide histone acetylation analysis reveals altered transcriptional regulation in the Parkinson's disease brain.

ABSTRACT:

Background

Parkinson's disease (PD) is a complex, age-related neurodegenerative disorder of largely unknown etiology. PD is strongly associated with mitochondrial respiratory dysfunction, which can lead to epigenetic dysregulation and specifically altered histone acetylation. Nevertheless, and despite the emerging role of epigenetics in age-related brain disorders, the question of whether aberrant histone acetylation is involved in PD remains unresolved.

Methods

We studied fresh-frozen brain tissue from two independent cohorts of individuals with idiopathic PD (n = 28) and neurologically healthy controls (n = 21). We performed comprehensive immunoblotting to identify histone sites with altered acetylation levels in PD, followed by chromatin immunoprecipitation sequencing (Ch

SUBMITTER: Toker L 

PROVIDER: S-EPMC8097820 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature