Impact of mixed meal tolerance test composition on measures of beta-cell function in type 2 diabetes.

ABSTRACT:

Background

Application of mixed meal tolerance tests (MMTT) to measure beta-cell function in long-term studies is limited by modification of the commercial products occurring over time. This study assessed the intra-individual reliability of MMTTs and compared the effects of liquid meals differing in macronutrient composition on the estimation of beta-cell function in type 2 diabetes (T2DM).

Methods

To test the reliability of MMTTs, 10 people with T2DM (age 58 ± 11 years, body mass index 30.0 ± 4.9 kg/m²) received Boost® high Protein 20 g protein three times. For comparing different meals, another 10 persons with T2DM (58 ± 5 years, 31.9 ± 5.3 kg/m²) ingested either Boost® high Protein 20 g protein or the isocaloric Boost® high Protein 15 g protein cont

SUBMITTER: Kossler T 

PROVIDER: S-EPMC8097850 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature