Benefit of replanning in MR-guided online adaptive radiation therapy in the treatment of liver metastasis.

ABSTRACT:

Purpose

To assess the effects of daily adaptive MR-guided replanning in stereotactic body radiation therapy (SBRT) of liver metastases based on a patient individual longitudinal dosimetric analysis.

Methods

Fifteen patients assigned to SBRT for oligometastatic liver metastases underwent daily MR-guided target localization and on-table treatment plan re-optimization. Gross tumor volume (GTV) and organs at risk (OARs) were adapted to the anatomy-of-the-day. A reoptimized plan (RP) and a rigidly shifted baseline plan (sBP) without re-optimization were generated for each fraction. After extraction of DVH parameters for GTV, planning target volume (PTV), and OARs (stomach, duodenum, bowel, liver, heart) plans were compared on a per-patient basis.

Results

Median pre-treatme

SUBMITTER: Mayinger M 

PROVIDER: S-EPMC8097956 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature