The unpredictable carbon nanotube biocorona and a functionalization method to prevent protein biofouling.

ABSTRACT:

Background

The intrinsic physicochemical properties of carbon nanotubes (CNTs) make them unique tools in nanotechnology. Their elemental composition, resilience, thermal properties, and surface reactivity make CNTs also of undisputed interest in biotechnology. In particular, their extraordinary ability to capture biomolecules on their surface makes them essential in this field. The proteins adsorbed on the CNTs create a biological coating that endows them the ability to interact with some cell receptors, penetrate membranes or interfere with cell biomechanics, thus behaving as an active bio-camouflage. But some of these proteins unfold, triggering an immune response that unpredictably changes the biological activity of CNTs. For this reason, the control of the biocorona is fundamen

SUBMITTER: Garcia-Hevia L 

PROVIDER: S-EPMC8097984 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature