Corilagin prevents SARS-CoV-2 infection by targeting RBD-ACE2 binding.

ABSTRACT:

Background

The outbreak of coronavirus (SARS-CoV-2) disease caused more than 100,000,000 people get infected and over 2,200,000 people being killed worldwide. However, the current developed vaccines or drugs may be not effective in preventing the pandemic of COVID-19 due to the mutations of coronavirus and the severe side effects of the newly developed vaccines. Chinese herbal medicines and their active components play important antiviral activities. Corilagin exhibited antiviral effect on human immunodeficiency virus (HIV), hepatitis C virus (HCV) and Epstein-Barr virus (EBV). However, whether it blocks the interaction between SARS-CoV-2 RBD and hACE2 has not been elucidated.

Purpose

To characterize an active compound, corilagin derived from Phyllanthus urinaria as potentia

SUBMITTER: Yang LJ 

PROVIDER: S-EPMC8098048 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature