Cost-Effectiveness of Management Algorithms for Lung-RADS Category 4 Nodules.

ABSTRACT:

Purpose

To evaluate nodule management guidelines in a simulated cohort of Lung Reporting and Data System (Lung-RADS) 4 nodules based on real-world data.

Materials and methods

In this retrospective study, 100 000 patients were simulated from 151 patients with Lung-RADS 4 nodules (from January 2010 to August 2018). Each patient in the simulation was managed with each algorithm, and health outcomes were accumulated based on interventions and delays to cancer diagnosis. If the algorithm missed a cancer, it was diagnosed at the next annual screening round, although it would grow in the interim. Patient age-specific or cancer-specific mortality was assigned depending on whether the nodule was malignant, and quality-adjusted life years (QALYs) were calculated. Costs of intervention

SUBMITTER: Hammer MM 

PROVIDER: S-EPMC8098088 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature