Comparison of CT Lung Density Measurements between Standard Full-Dose and Reduced-Dose Protocols.

ABSTRACT:

Purpose

To evaluate the reproducibility and predicted clinical outcomes of CT-based quantitative lung density measurements using standard fixed-dose (FD) and reduced-dose (RD) scans.

Materials and methods

In this retrospective analysis of prospectively acquired data, 1205 participants (mean age, 65 years ± 9 [standard deviation]; 618 men) enrolled in the COPDGene study who underwent FD and RD CT image acquisition protocols between November 2014 and July 2017 were included. Of these, the RD scans of 640 participants were also reconstructed using iterative reconstruction (IR). Median filtering was applied to the RD scans (RD-MF) to investigate an alternative noise reduction strategy. CT attenuation at the 15th percentile of the lung CT histogram (Perc15) was computed for all i

SUBMITTER: Hatt CR 

PROVIDER: S-EPMC8098098 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature