Genetically predicted serum vitamin D and COVID-19: a Mendelian randomisation study.

ABSTRACT:

Objectives

To investigate causality of the association of serum vitamin D with the risk and severity of COVID-19 infection.

Design

Two-sample Mendelian randomisation study.

Setting

Summary data from genome-wide analyses in the population-based UK Biobank and SUNLIGHT Consortium, applied to meta-analysed results of genome-wide analyses in the COVID-19 Host Genetics Initiative.

Participants

17 965 COVID-19 cases including 11 085 laboratory or physician-confirmed cases, 7885 hospitalised cases and 4336 severe respiratory cases, and 1 370 547 controls, primarily of European ancestry.

Exposures

Genetically predicted variation in serum vitamin D status, instrumented by genome-wide significant single nucleotide polymorphisms (SNPs) associated with serum vitamin

SUBMITTER: Patchen BK 

PROVIDER: S-EPMC8098235 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature