Histomorphological patterns of regional lymph nodes in COVID-19 lungs.

ABSTRACT:

Background

A dysregulated immune response is considered one of the major factors leading to severe COVID-19. Previously described mechanisms include the development of a cytokine storm, missing immunoglobulin class switch, antibody-mediated enhancement, and aberrant antigen presentation.

Objectives

To understand the heterogeneity of immune response in COVID-19, a thorough investigation of histomorphological patterns in regional lymph nodes was performed.

Materials and methods

Lymph nodes from the cervical, mediastinal, and hilar regions were extracted from autopsies of patients with lethal COVID-19 (n = 20). Histomorphological characteristics, SARS-CoV‑2 qRT-PCR, and gene expression profiling on common genes involved in immunologic response were analyzed.

Results</

SUBMITTER: Haslbauer JD 

PROVIDER: S-EPMC8098637 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature