Neurobiology, Clinical Presentation, and Treatment of Methamphetamine Use Disorder: A Review.

ABSTRACT:

Importance

The prevalence of and mortality associated with methamphetamine use has doubled during the past 10 years. There is evidence suggesting that methamphetamine use disorder could be the next substance use crisis in the United States and possibly worldwide.

Observation

The neurobiology of methamphetamine use disorder extends beyond the acute effect of the drug as a monoaminergic modulator and includes intracellular pathways focused on oxidative stress, neurotoxic and excitotoxic effects, and neuroinflammation. Similarly, the clinical picture extends beyond the acute psychostimulatory symptoms to include complex cardiovascular and cerebrovascular signs and symptoms that need to be identified by the clinician. Although there are no pharmacologic treatments for methamphet

SUBMITTER: Paulus MP 

PROVIDER: S-EPMC8098650 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature