Endothelial-Dependent Vasomotor Dysfunction in Infants After Cardiopulmonary Bypass.

ABSTRACT:

Objectives

Cardiopulmonary bypass-induced endothelial dysfunction has been inferred by changes in pulmonary vascular resistance, alterations in circulating biomarkers, and postoperative capillary leak. Endothelial-dependent vasomotor dysfunction of the systemic vasculature has never been quantified in this setting. The objective of the present study was to quantify acute effects of cardiopulmonary bypass on endothelial vasomotor control and attempt to correlate these effects with postoperative cytokines, tissue edema, and clinical outcomes in infants.

Design

Single-center prospective observational cohort pilot study.

Setting

Pediatric cardiac ICU at a tertiary children's hospital.

Patients

Children less than 1 year old requiring cardiopulmonary bypass for repai

SUBMITTER: Krispinsky LT 

PROVIDER: S-EPMC8098768 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature