Randomised controlled trial of oxygen therapy and high-flow nasal therapy in African children with pneumonia.

ABSTRACT:

Purpose

The life-saving role of oxygen therapy in African children with severe pneumonia is not yet established.

Methods

The open-label fractional-factorial COAST trial randomised eligible Ugandan and Kenyan children aged > 28 days with severe pneumonia and severe hypoxaemia stratum (SpO₂ < 80%) to high-flow nasal therapy (HFNT) or low-flow oxygen (LFO: standard care) and hypoxaemia stratum (SpO₂ 80-91%) to HFNT or LFO (liberal strategies) or permissive hypoxaemia (ratio 1:1:2). Children with cyanotic heart disease, chronic lung disease or > 3 h receipt of oxygen were excluded. The primary endpoint was 48 h mortality; secondary endpoints included mortality or neurocognitive sequelae at 28 days.

Results

The trial was stopped early after enrolling

SUBMITTER: Maitland K 

PROVIDER: S-EPMC8098782 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature