Methodological Quality Assessment of Budget Impact Analyses for Orphan Drugs: A Systematic Review.

ABSTRACT: Objectives: This research aims to evaluate the methodological quality of budget impact analyses for orphan drugs and to provide suggestions for future analyses. Methods: Conference abstracts and peer-reviewed literature on budget impact analyses were collected through searches of Pubmed and Embase. ISPOR good practice guidelines were used as a methodological standard for budget impact analyses. Examined parameters encompassed: perspective, target population, data sources, intervention and comparator(s), time horizon, scope of costs, discounting, validation, assumptions and sensitivity analysis. Results: Seventy studies on individual orphan drugs and 21 studies on a combination of orphan drugs analyzing budget impact were identified. Overall, analyses considered a third

SUBMITTER: Abdallah K 

PROVIDER: S-EPMC8098807 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature