Genetic markers for treatment-related pancreatitis in a cohort of Hispanic children with acute lymphoblastic leukemia.

ABSTRACT:

Purpose

Treatment-related pancreatitis (TRP) is a serious complication occurring in children with acute lymphoblastic leukemia (ALL). Those affected are at high risk for severe organ toxicity and treatment delays that can impact outcomes. TRP is associated with asparaginase, a standard therapeutic agent in childhood ALL. Native American ancestry, older age, high-risk leukemia, and increased use of asparaginase are linked to pancreatitis risk. However, dedicated genetic studies evaluating pancreatitis in childhood ALL include few Hispanics. Thus, the genetic basis for higher risk of pancreatitis among Hispanic children with ALL remains unknown.

Methods

Cases of children with ALL treated in from 1994 through 2013 were reviewed and identified 14, all Hispanic, who developed pan

SUBMITTER: Grimes AC 

PROVIDER: S-EPMC8098858 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature