Airway macrophage-intrinsic TGF-β1 regulates pulmonary immunity during early-life allergen exposure.

ABSTRACT:

Background

Early life represents a major risk window for asthma development. However, the mechanisms controlling the threshold for establishment of allergic airway inflammation in early life are incompletely understood. Airway macrophages (AMs) regulate pulmonary allergic responses and undergo TGF-β-dependent postnatal development, but the role of AM maturation factors such as TGF-β in controlling the threshold for pathogenic immune responses to inhaled allergens remains unclear.

Objective

Our aim was to test the hypothesis that AM-derived TGF-β1 regulates pathogenic immunity to inhaled allergen in early life.

Methods

Conditional knockout (Tgfb1^ΔCD11c) mice, with TGF-β1 deficiency in AMs and other CD11c⁺ cells, were analyzed throughout early life

SUBMITTER: Branchett WJ 

PROVIDER: S-EPMC8098862 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature