Sources of the frontocentral mismatch negativity and P3a responses in schizophrenia patients and healthy comparison subjects.

ABSTRACT:

Background

Mismatch negativity (MMN) and P3a are event-related potential measures of early auditory information processing that are increasingly used as translational biomarkers in the development of treatments for neuropsychiatric disorders. These responses are reduced in schizophrenia patients over the frontocentral scalp electrodes and are associated with important domains of cognitive and psychosocial functioning. While MMN and P3a responses are generated by a dynamic network of cortical sources distributed across the temporal and frontal brain regions, it is not clear how these sources independently contribute to MMN and P3a at the primary frontocentral scalp electrode or to abnormalities observed in schizophrenia. This study aimed to determine the independent source contribut

SUBMITTER: Koshiyama D 

PROVIDER: S-EPMC8099045 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature