Effects of ectoine containing nasal spray and eye drops on symptoms of seasonal allergic rhinoconjunctivitis.

ABSTRACT:

Background

Patients are often dissatisfied with the symptom control obtained from available pharmacological treatments for seasonal allergic rhinoconjunctivitis (ARC). Therefore, patients seek for alternative, nonpharmacological options to treat their symptoms. Here, we assessed the efficacy of ectoine nasal spray and ectoine eye drops in comparison to placebo to prevent nasal and ocular symptoms following exposure to pollen in patients with ARC.

Methods

In this double-blind, randomized, placebo-controlled, cross-over study, 46 patients with ARC applied ectoine eye drops and nasal spray in immediate succession or placebo eye drops and nasal spray for 13 days before ARC symptoms were induced in an environmental exposure chamber. Primary endpoint was the baseline-adjusted area

SUBMITTER: Salapatek AM 

PROVIDER: S-EPMC8099269 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature