Associations of meningioma molecular subgroup and tumor recurrence.

ABSTRACT:

Background

We and others have identified mutually exclusive molecular subgroups of meningiomas; however, the implications of this classification for clinical prognostication remain unclear. Integrated genomic and epigenomic analyses implicate unique oncogenic processes associated with each subgroup, suggesting the potential for divergent clinical courses. The aim of this study was to understand the associated clinical outcomes of each subgroup, as this could optimize treatment for patients.

Methods

We analyzed outcome data for 469 meningiomas of known molecular subgroup, including extent of resection, postoperative radiation, surveillance imaging, and time to recurrence, when applicable. Statistical relationships between outcome variables and subgroup were assessed. Features

SUBMITTER: Youngblood MW 

PROVIDER: S-EPMC8099468 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature