Patient-derived orthotopic xenograft models of medulloblastoma lack a functional blood-brain barrier.

ABSTRACT:

Background

Novel targeted therapies for children diagnosed with medulloblastoma (MB), the most common malignant pediatric brain tumor, are urgently required. A major hurdle in the development of effective therapies is the impaired delivery of systemic therapies to tumor cells due to a specialized endothelial blood-brain barrier (BBB). Accordingly, the integrity of the BBB is an essential consideration in any preclinical model used for assessing novel therapeutics. This study sought to assess the functional integrity of the BBB in several preclinical mouse models of MB.

Methods

Dynamic contrast enhancement magnetic resonance imaging (MRI) was used to evaluate blood-brain-tumor barrier (BBTB) permeability in a murine genetically engineered mouse model (GEMM) of Sonic Hedgehog

SUBMITTER: Genovesi LA 

PROVIDER: S-EPMC8099473 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature