Association of supratotal resection with progression-free survival, malignant transformation, and overall survival in lower-grade gliomas.

ABSTRACT:

Background

Supratotal resection is advocated in lower-grade gliomas (LGGs) based on theoretical advantages but with limited verification of functional risk and data on oncological outcomes. We assessed the association of supratotal resection in molecularly defined LGGs with oncological outcomes.

Methods

Included were 460 presumptive LGGs; 404 resected; 347 were LGGs, 319 isocitrate dehydrogenase (IDH)-mutated, 28 wildtype. All patients had clinical, imaging, and molecular data. Resection aimed at supratotal resection without any patient or tumor a priori selection. The association of extent of resection (EOR), categorized on volumetric fluid attenuated inversion recovery images as residual tumor volume, along with postsurgical management with progression-free survival (PFS),

SUBMITTER: Rossi M 

PROVIDER: S-EPMC8099476 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature