DNA methylation regulator-mediated modification patterns and tumor microenvironment characterization in gastric cancer.

ABSTRACT: Growing evidence implies a link between DNA methylation and tumor immunity/immunotherapy. However, the global influence of DNA methylation on the characteristics of the tumor microenvironment and the efficacy of immunotherapy remains to be clarified. In this study, we systematically evaluated the DNA methylation regulator patterns and tumor microenvironment characteristics of 1,619 gastric cancer patients by clustering the gene expression of 20 DNA methylation regulators. Three gastric cancer subtypes that had different DNA methylation modification patterns and distinct tumor microenvironment characteristics were recognized. Then, a DNA methylation score (DMS) was constructed to evaluate DNA methylation modification individually. High DMS was characterized by immune activation status, incr

SUBMITTER: Meng Q 

PROVIDER: S-EPMC8099484 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature