Distinct transcriptomic landscapes of cutaneous basal cell carcinomas and squamous cell carcinomas.

ABSTRACT: The majority of non-melanoma skin cancer (NMSC) is cutaneous basal cell carcinoma (BCC) or squamous cell carcinoma (SCC), which are also called keratinocyte carcinomas, as both of them originate from keratinocytes. The incidence of keratinocyte carcinomas is over 5 million per year in the US, three-fold higher than the total incidence of all other types of cancer combined. While there are several reports on gene expression profiling of BCC and SCC, there are significant variations in the reported gene expression changes in different studies. One reason is that tumor-adjacent normal skin specimens were not included in many studies as matched controls. Furthermore, while numerous studies of skin stem cells in mouse models have been reported, their relevance to human skin cancer remains unkno

SUBMITTER: Wan J 

PROVIDER: S-EPMC8099692 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature