VB₁₀, a new blood biomarker for differential diagnosis and recovery monitoring of acute viral and bacterial infections.

ABSTRACT:

Background

Precise differential diagnosis between acute viral and bacterial infections is important to enable appropriate therapy, avoid unnecessary antibiotic prescriptions and optimize the use of hospital resources. A systems view of host response to infections provides opportunities for discovering sensitive and robust molecular diagnostics.

Methods

We combine blood transcriptomes from six independent datasets (n = 756) with a knowledge-based human protein-protein interaction network, identifies subnetworks capturing host response to each infection class, and derives common response cores separately for viral and bacterial infections. We subject the subnetworks to a series of computational filters to identify a parsimonious gene panel and a standalone diagnostic score tha

SUBMITTER: Ravichandran S 

PROVIDER: S-EPMC8099739 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature