Causes behind error rates for predictive biomarker testing: the utility of sending post-EQA surveys.

ABSTRACT: External quality assessment (EQA) schemes assess the performance of predictive biomarker testing in lung and colorectal cancer and have previously demonstrated variable error rates. No information is currently available on the underlying causes of incorrect EQA results in the laboratories. Participants in EQA schemes by the European Society of Pathology between 2014 and 2018 for lung and colorectal cancer were contacted to complete a survey if they had at least one analysis error or test failure in the provided cases. Of the 791 surveys that were sent, 325 were completed including data from 185 unique laboratories on 514 incorrectly analyzed or failed cases. For the digital cases and immunohistochemistry, the majority of errors were interpretation-related. For fluorescence in situ hybridiz

SUBMITTER: Keppens C 

PROVIDER: S-EPMC8099794 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature