Quantification of the early pupillary dilation kinetic to assess rod and cone activity.

ABSTRACT: Rods, cones and melanopsin contribute in various proportions, depending on the stimulus light, to the pupil light response. This study used a first derivative analysis to focus on the quantification of the dynamics of pupillary dilation that immediately follows light-induced pupilloconstriction in order to identify novel parameters that reflect rod and cone activity. In 18 healthy adults, the pupil response to a 1 s blue light stimulus ranging from - 6.0 to 2.65 log cd/m² in dark-adapted conditions and to a 1 s blue light stimulus (2.65 log cd/m²) in light-adapted conditions was recorded on a customized pupillometer. Three derivative parameters which describe the 2.75 s following the light onset were quantified: dAMP (maximal amplitude of the positive peak), dLAT (lat

SUBMITTER: Kostic C 

PROVIDER: S-EPMC8099900 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature