Identification of molecular signatures associated with early relapse after complete resection of lung adenocarcinomas.

ABSTRACT: The only potentially curative treatment for lung adenocarcinoma patients remains complete resection of early-stage tumors. However, many patients develop recurrence and die of their disease despite curative surgery. Underlying mechanisms leading to establishment of systemic disease after complete resection are mostly unknown. We therefore aimed at identifying molecular signatures of resected lung adenocarcinomas associated with the risk of an early relapse. The study comprised 89 patients with totally resected stage IA-IIIA lung adenocarcinomas. Patients suffering from an early relapse within two years after surgery were compared to patients without a relapse in two years. Patients were clinically and molecular pathologically characterized. Tumor tissues were immunohistochemically analyzed

SUBMITTER: Pasternack H 

PROVIDER: S-EPMC8099905 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature