Blunted PTH response to vitamin D insufficiency/deficiency and colorectal neoplasia risk.

ABSTRACT:

Background & aims

In contrast to many observational studies, large-scale randomized trials do not support the protective role of vitamin D for the prevention of colorectal neoplasia. However, in previous studies, individuals with blunted parathyroid hormone (PTH) response to vitamin D insufficiency/deficiency (BPRVID), were not differentiated from those with high PTH response to vitamin D insufficiency/deficiency (HPRVID). Individuals with BPRVID are responsive to magnesium treatment, particularly treatment of magnesium plus vitamin D while those with HPRVID are responsive to vitamin D treatment. We prospectively compared these two distinct groups (i.e. BPRVID and HPRVID) for risk of incident adenoma, metachronous adenoma, and incident colorectal cancer (CRC) METHODS: Three nested

SUBMITTER: Hellwege JN 

PROVIDER: S-EPMC8099932 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature