Early nutrition and white matter microstructure in children born very low birth weight.

ABSTRACT: Infants born at very low birth weight (<1500 g) are vulnerable to nutritional deficits during their first postnatal month, which are associated with poor neurodevelopmental outcomes. Despite this knowledge, the impact of early postnatal nutrition on white matter microstructure in children born with very low birth weight has not been investigated. In this prospective cohort study, we employed a whole-brain approach to investigate associations between precise estimates of nutrient intake within the first postnatal month with white matter microstructure at 5 years of age. Detailed information about breastmilk, macronutrient and energy intakes during this period were prospectively recorded for all participants. Multi-shell diffusion and T₁-weighted MRIs were acquired in 41 children

SUBMITTER: Sato J 

PROVIDER: S-EPMC8100003 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature