IL-4Rα signaling by CD8α⁺ dendritic cells contributes to cerebral malaria by enhancing inflammatory, Th1, and cytotoxic CD8⁺ T cell responses.

ABSTRACT: Persistent high levels of proinflammatory and Th1 responses contribute to cerebral malaria (CM). Suppression of inflammatory responses and promotion of Th2 responses prevent pathogenesis. IL-4 commonly promotes Th2 responses and inhibits inflammatory and Th1 responses. Therefore, IL-4 is widely considered as a beneficial cytokine via its Th2-promoting role that is predicted to provide protection against severe malaria by inhibiting inflammatory responses. However, IL-4 may also induce inflammatory responses, as the result of IL-4 action depends on the timing and levels of its production and the tissue environment in which it is produced. Recently, we showed that dendritic cells (DCs) produce IL-4 early during malaria infection in response to a parasite protein and that this IL-4 response m

SUBMITTER: Wu X 

PROVIDER: S-EPMC8100064 | biostudies-literature | 2021 Jan-Jun

REPOSITORIES: biostudies-literature