Beta-lactam-induced immediate hypersensitivity reactions: A genome-wide association study of a deeply phenotyped cohort.

ABSTRACT:

Background

β-lactam antibiotics are associated with a variety of immune-mediated or hypersensitivity reactions, including immediate (type I) reactions mediated by antigen-specific IgE.

Objective

We sought to identify genetic predisposing factors for immediate reactions to β-lactam antibiotics.

Methods

Patients with a clinical history of immediate hypersensitivity reactions to either penicillins or cephalosporins, which were immunologically confirmed, were recruited from allergy clinics. A genome-wide association study was conducted on 662 patients (the discovery cohort) with a diagnosis of immediate hypersensitivity and the main finding was replicated in a cohort of 98 Spanish cases, recruited using the same diagnostic criteria as the discovery cohort.

Results

SUBMITTER: Nicoletti P 

PROVIDER: S-EPMC8100096 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature