Iron induces two distinct Ca²⁺ signalling cascades in astrocytes.

ABSTRACT: Iron is the fundamental element for numerous physiological functions. Plasmalemmal divalent metal ion transporter 1 (DMT1) is responsible for cellular uptake of ferrous (Fe²⁺), whereas transferrin receptors (TFR) carry transferrin (TF)-bound ferric (Fe³⁺). In this study we performed detailed analysis of the action of Fe ions on cytoplasmic free calcium ion concentration ([Ca²⁺]_i) in astrocytes. Administration of Fe²⁺ or Fe³⁺ in μM concentrations evoked [Ca²⁺]_i in astrocytes in vitro and in vivo. Iron ions trigger increase in [Ca²⁺]_i through two distinct molecular cascades. Uptake of Fe²⁺ by DMT1 inhibits astroglial Na⁺-K⁺-ATPase, which leads to elev

SUBMITTER: Guan W 

PROVIDER: S-EPMC8100120 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature