Rodent Models for the Study of Soil-Transmitted Helminths: A Proteomics Approach.

ABSTRACT: Soil-transmitted helminths (STH) affect hundreds of millions worldwide and are some of the most important neglected tropical diseases in terms of morbidity. Due to the difficulty in studying STH human infections, rodent models have become increasingly used, mainly because of their similarities in life cycle. Ascaris suum and Trichuris muris have been proven appropriate and low maintenance models for the study of ascariasis and trichuriasis. In the case of hookworms, despite most of the murine models do not fully reproduce the life cycle of Necator americanus, their proteomic similarity makes them highly suitable for the development of novel vaccine candidates and for the study of hookworm biological features. Furthermore, these models have been helpful in elucidating s

SUBMITTER: Montano KJ 

PROVIDER: S-EPMC8100317 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature