When MINMOD Artifactually Interprets Strong Insulin Secretion as Weak Insulin Action.

ABSTRACT: We address a problem with the Bergman-Cobelli Minimal Model, which has been used for 40 years to estimate S _I during an intravenous glucose tolerance test (IVGTT). During the IVGTT blood glucose and insulin concentrations are measured in response to an acute intravenous glucose load. Insulin secretion is often assessed by the area under the insulin curve during the first few minutes (Acute Insulin Response, AIR). The issue addressed here is that we have found in simulated IVGTTs, representing certain contexts, Minimal Model estimates of S _I are inversely related to AIR, resulting in artifactually lower S _I . This may apply to Minimal Model studies reporting lower S _I in Blacks than in

SUBMITTER: Ha J 

PROVIDER: S-EPMC8100339 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature