Antiplasmodial activity of the natural product compounds alstonine and himbeline.

ABSTRACT: Malaria, caused by Plasmodium parasites, continues to be a devastating global health issue. Despite a decline in malaria related deaths over the last decade, overall progress has plateaued. Key challenges to malaria prevention and control include the lack of a broadly effective vaccine and parasite drug resistance, including to the current gold standard artemisinin combination therapies (ACTs). New drugs with unique modes of action are therefore a priority for both the treatment and prevention of malaria. Unlike treatment drugs which need to kill parasites quickly to reduce or prevent clinical symptoms, compounds that kill parasites more slowly may be an option for malaria prevention. Natural products and natural product derived compounds have historically been an excellent source of antim

SUBMITTER: Arnold MSJ 

PROVIDER: S-EPMC8100350 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature