Psychological well-being of early and continuously treated phenylketonuria patients.

ABSTRACT:

Background

Despite enormous advances in therapy, phenylketonuria (PKU) remains an incurable, inherited metabolic disease requiring life-long treatment with potential to negatively impact quality of life and psychological well-being. Therefore, the aim of this study was to screen early diagnosed and continuously treated children with PKU on psychological strengths and behavioral difficulties.

Methods

Evaluation of psychological strengths and behavioral difficulties in 49 patients with PKU (23f, 2-17 years) by Strengths and Difficulties Questionnaire (SDQ; self-report 11-17 years and parent-report 2-17 years). Comparison to age, sex and BMI-matched healthy controls (n = 98; 46f).

Results

In patients with PKU and healthy controls median SDQ Total Difficulties Score and m

SUBMITTER: Thiele AG 

PROVIDER: S-EPMC8100406 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature