Pan-Cancer Analysis of FURIN as a Potential Prognostic and Immunological Biomarker.

ABSTRACT:

Background

Furin is a calcium-dependent protease that processes various precursor proteins through diverse secretory pathways. The deregulation of FURIN correlated with the prognosis of patients in numerous diseases. However, the role of FURIN in human pan-cancer is still largely unknown.

Methods

Multiple bioinformatic methods were employed to comprehensively analyze the correlation of FURIN expression with prognosis, mismatch repair (MMR), microsatellite instability (MSI), tumor mutational burden (TMB), DNA methylation, tumor immune infiltration, and common immune checkpoint inhibitors (ICIs) from the public database, and aim to evaluate the potential prognostic value of FURIN across cancers.

Results

FURIN was aberrantly expressed and was strongly correlated with MMR

SUBMITTER: Zhou B 

PROVIDER: S-EPMC8100462 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature