Inhibition of Small-Conductance, Ca²⁺-Activated K⁺ Current by Ondansetron.

ABSTRACT: Background: Small-conductance Ca²⁺-activated K⁺ channels (SK channels) have been proposed as antiarrhythmic targets for the treatment of atrial fibrillation. We previously demonstrated that the 5-HT₃ receptor antagonist ondansetron inhibits heterologously expressed, human SK2 (hSK2) currents as well as native cardiac SK currents in a physiological extra-/intracellular [K⁺] gradient at therapeutic (i.e., sub-micromolar) concentrations. A recent study, using symmetrical [K⁺] conditions, challenged this result. The goal of the present study was to revisit the inhibitory effect of ondansetron on hSK2-mediated currents in symmetrical [K⁺] conditions. Experimental Approach: The whole-cell patch clamp technique was us

SUBMITTER: Guo S 

PROVIDER: S-EPMC8100601 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature