Alteration of Gut Microbiome and Correlated Lipid Metabolism in Post-Stroke Depression.

ABSTRACT:

Background

The pathogenesis of post-stroke depression (PSD) remains largely unknown. There is growing evidence indicating that gut microbiota participates in the development of brain diseases through the gut-brain axis. Here, we aim to determine whether and how microbial composition and function altered among control, stroke and PSD rats.

Materials and methods

After the PSD rat model was successfully established, gut microbiome combined with fecal metabolome approach were performed to identify potentially PSD-related gut microbes and their functional metabolites. Then, correlations between behavior indices and altered gut microbes, as well as correlations between altered gut microbial operational taxonomic units (OTUs) with differential metabolites in PSD rats were explored.

SUBMITTER: Jiang W 

PROVIDER: S-EPMC8100602 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature