Specific sub-regions along the longitudinal axis of the hippocampus mediate antidepressant-like behavioral effects.

ABSTRACT: Current antidepressants are suboptimal due incomplete understanding of the neurobiology underlying their behavioral effects. However, imaging studies suggest the hippocampus is a key brain region underpinning antidepressant action. There is increasing attention on the functional segregation of the hippocampus into a dorsal region (dHi) predominantly involved in spatial learning and memory, and a ventral region (vHi) which regulates anxiety, a symptom often co-morbid with depression. However, little is known about the roles of these hippocampal sub-regions in the antidepressant response. Moreover, the area between them, the intermediate hippocampus (iHi), has received little attention. Here, we investigated the impact of dHi, iHi or vHi lesions on anxiety- and depressive-like behaviors unde

SUBMITTER: Levone BR 

PROVIDER: S-EPMC8100619 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature