In vivo tensor-valued diffusion MRI of focal demyelination in white and deep grey matter of rodents.

ABSTRACT:

Background

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease leading to damage of white matter (WM) and grey matter (GM). Magnetic resonance imaging (MRI) is the modality of choice to assess brain damage in MS, but there is an unmet need in MRI for achieving higher sensitivity and specificity to MS-related microstructural alterations in WM and GM.

Objective

To explore whether tensor-valued diffusion MRI (dMRI) can yield sensitive microstructural read-outs for focal demyelination in cerebral WM and deep GM (DGM).

Methods

Eight rats underwent L-α-Lysophosphatidylcholine (LPC) injections in the WM and striatum to introduce focal demyelination. Multimodal MRI was performed at 7 Tesla after 7 days. Tensor-valued dMRI was complemented by diffusion tens

SUBMITTER: He Y 

PROVIDER: S-EPMC8100629 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature